Fig. 10.

Prior CS exposure increases inflammatory cell cytotoxic proteins during pneumococcal pneumonia. A: CS-exposed mice had greater myeloperoxidase activity than air-exposed mice, *by Mann-Whitney. B: lung levels of granzyme B, a serine protease contained in cytotoxic lymphocyte granules, were not significantly increased by prior CS exposure, P = 0.14 by Mann-Whitney. C: granzyme B levels were unrelated to the level of pulmonary edema in air-exposed mice, Spearman r = −0.07, P = 0.81. D: in contrast, granzyme B levels predicted the extent of pulmonary edema in CS-exposed mice, Spearman r = 0.58, P = 0.04.