Table 1.
Inhibition roles of Cordycepin on tumor growth.
| Tumor types (cell lines) | Mechanism of anti-tumor | Molecular targets | References |
|---|---|---|---|
| Human gastric cancer (SGC-7901) | Induction of apoptosis | PI3K/AKT↑ | (Nasser et al., 2017) |
| Human non-small cell lung cancer cells | Induction of apoptosis/autophagy | c-FLIPL↓ | (Yu et al., 2017) |
| Human liver cancer (HepG2) | Induction of apoptosis | Caspase-8, Fas, FADD↑ | (Shao et al., 2016) |
| Human renal cancer cells (TK-10) | Induction of apoptosis | MKK7, JNK↑ | (Hwang et al., 2017a) |
| Human uterine cervical cancer cell (ME180 and HeLa cell) | Induction of G2/M arrest | Cyclin A2↓ | (Seong da et al., 2016) |
| Human Leukemia cells (NB-4 and U937 cells) | Induction of apoptosis/cell cycle arrest | Cyclin A2, cyclin E, and CDK2↓ p53↑ | (Liao et al., 2015) |
| Human Bladder cancer (T-24) | Induction of apoptosis | A3 adenosine receptors↑ | (Cao et al., 2017) |
| Human bladder cancer cell (5637 and T-24 cells) | G2/M cell cycle arrest | Phosphorylation of c-Jun | (Lee et al., 2009) |
| Human breast cancer cells (MCF-7 and MDA-MB-231) | Induction of apoptosis | Caspase-3,8,9↑, BCL-2↓ | (Wang et al., 2016) |
| Murine oral cancer (4NAOC-1) | Induction of apoptosis, decrease cell mitosis and EGFR signaling | Caspase-3↑ EGFR, IL-17RA↓ | (Hsu et al., 2017) |
| Murine Leydig tumor cell (MA-10) | Induction of apoptosis | p38 MAPK↑ | (Hsu et al., 2017) |