Table 2.
Inhibition roles of Cordycepin on tumor migration and metastasis.
| Tumor types (cell lines) | Anti-metastatic mechanism | Molecular targets | References |
|---|---|---|---|
| Human oral squamous cell carcinoma | Inhibition of epithelial-mesenchymal transition (EMT) | E-cadherin, N-cadherin↓ | (Su et al., 2017) |
| Human hepatocellular carcinoma (HepG2) | Anti-metastatic and anti-angiogenic | (Lu et al., 2014) | |
| Human glioblastoma cell (U87MG and LN229) | Inhibition of tumor cell motility | Lysosomal degradation, protein phosphatase activation↑ | (Hueng et al., 2017) |
| Human prostate carcinoma (LNCaP) | Inhibition of migration and invasion of tumor | AKT↓ | (Jeong et al., 2012) |
| Human ovarian carcinoma (OVCAR-3) | EMT | Mitochondrial activity↓, Estrogen-related receptor α↓ | (Wang et al., 2017b) |
| Human melanoma | Inhibition of invasion and metastasis | miR-33b↓, HMGA2, Twist1, ZEB1↑ | (Zhang et al., 2015) |