Table 1.

Top 10 Molecular function pathways/groups enriched by 1669 genes reported.

Pathway/gene set name	GO ID	# of Entities	Overlap	q-value	Jaccard similarity
Aging	0016280	254	140	2.28E−84	0.077
Neuronal cell body	0043025	466	172	4.7E−72	0.086
Neuron projection	0043005	378	153	2.8E−70	0.079
Response to lipopolysaccharide	0032496	252	126	4.9E−69	0.069
Response to hypoxia	0001666	259	127	8.11E−68	0.069
Response to organic cyclic compound	0014070	253	122	1.79E−64	0.067
Response to ethanol	0017036	161	94	4.21E−59	0.053
Negative regulation of apoptotic process	0006916	650	187	1.21E−56	0.086
Perinuclear region of cytoplasm	0048471	688	188	2.11E−55	0.085
Axon	0030424	318	125	2.56E−55	0.066

For each gene set, the p-value was calculated using Fisher’s-Exact test against the hypothesis that a randomly selected gene group of same size (1669) can generate a same or higher overlap with the corresponding gene set (q = 0.001 for FDR correction). The Jaccard similarity (j_s) is a statistic used for comparing the similarity and diversity of sample sets, which is defined by $j_s(A\text{,}B)=\frac{A\cap B}{A\cup B}$ where A and B are two sample sets.