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Effect of DUSP1 on MAPK signaling pathway. (A) PC-3 cells overexpressing DUSP1 were transfected with a MAPK luciferase-reporter construct. (B) PC-3 cells with DUSP1 knockdown were transfected with MAPK luciferase-reporter construct. MAPK activity was normalized to Renilla luciferase activity. Results were mean ± SE (n = 3). *P < 0.05 vs WT; **P < 0.05 vs Con-OE or Sh-Con.
