FIGURE 2.

Simplified functional connectivity of hypoxia-responsive pontine neurons

A–E: interactions inferred from various experimental approaches reviewed in the text that contribute to the hypoxic ventilatory response and changes in cardiorespiratory coupling during hypoxia in current models. F and G: MWRO-triggered firing rate histograms of a pontine neuron before and after bilateral vagotomy and phase resetting of MWROs by withholding lung inflation in vagus-intact cat. Figure derived from Fig. 5A in Ref. 176 with permission. See text for details. KF, Kölliker-Fuse n.; LPBM, lateral parabrachial n.; MWRO, Mayer wave-related oscillations; NPBM, medial parabrachial n.; Ti (Te), duration of inspiratory (expiratory) phase.