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The complex interplay between the HPA axis and adipose tissue during development. H indicates that hypoxia can play a significant role in altering the plasticity of all of these components. Solid lines represent stimulatory pathways, whereas dashed lines are indicative of inhibitory pathways. ACTH, adrenocorticotropic hormone; ARC, arcuate nucleus; CRH, corticotropin-releasing hormone; LHA, lateral hypothalamic area; NTS, nucleus tractus solitarius; PVN, paraventricular nucleus.
