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. 2018 May 2;98(3):1241–1334. doi: 10.1152/physrev.00043.2017

Table 3.

Antenatal hypoxia and developmental plasticity

Species Offspring Phenotypes of Disorders and Diseases Reference Nos.
Human Pulmonary vascular dysfunction and hypertension 430, 451, 882
Congenital heart disease 574
Increased microvessel density 298
Schizophrenia 129, 357, 734, 1004
Autism 118
Activation of the magnocellular neuroendocrine neurons 757
Decreased verbal IQ 32
Sheep Pulmonary vascular dysfunction and hypertension 370, 371, 570
Systemic vascular dysfunction 370, 684
Decreased cardiomyocyte endowment 96
Coronary tree remodeling with increased conductance 108, 209
Rodent Increased ischemic heart injury 552, 553, 784, 785, 838, 1089, 1100, 1104, 1108
Chronic cardiopulmonary dysfunction 862
Congenital heart disease 126, 913, 1126
Decreased cardiac output 359
Decreased ventricular stiffness 358
Decreased coronary flow reserve 360
Myocardial thinning 828
Decreased cardiomyocyte endowment 47, 49, 553, 767, 985
Matrix metalloproteinases and cardiac remodeling 986
Increased blood pressure 794, 851, 859, 945, 1078, 1080, 1083, 1086
Endothelial dysfunction and aging 23, 99, 184, 310, 365, 690, 839, 1021
Systemic vascular dysfunction 1061, 1062, 1075, 1079, 1081, 1087
Atherosclerosis 1037, 1153
Pulmonary vascular dysfunction and hypertension 445, 621, 797
Metabolic dysfunction 127, 412, 479, 754, 861
Renal vascular dysfunction 957
Kidney development defects 321, 1057, 1071
Reduced bone mass and density 537
Liver enzyme dysfunction and fatty liver disease 754, 938
Retinal dysfunction 100
Changed salt appetite and body fluid regulations 1117
Impaired respiratory behavior 795, 796
Altered adrenal medulla maturation 617
Increased sensitivity to ischemic brain injury 322, 558, 559
Alzheimer's disease 1157
Schizophrenia 385
Sensitized HPA reactivity to stress and anxiety-like behavior 259, 819, 869, 1033
Impaired circadian synchronization and biological clock to light 448
Cognitive dysfunctions 231, 318, 963
Cerebral white matter damage 1024