Table 3.
Antenatal hypoxia and developmental plasticity
Species | Offspring Phenotypes of Disorders and Diseases | Reference Nos. |
---|---|---|
Human | Pulmonary vascular dysfunction and hypertension | 430, 451, 882 |
Congenital heart disease | 574 | |
Increased microvessel density | 298 | |
Schizophrenia | 129, 357, 734, 1004 | |
Autism | 118 | |
Activation of the magnocellular neuroendocrine neurons | 757 | |
Decreased verbal IQ | 32 | |
Sheep | Pulmonary vascular dysfunction and hypertension | 370, 371, 570 |
Systemic vascular dysfunction | 370, 684 | |
Decreased cardiomyocyte endowment | 96 | |
Coronary tree remodeling with increased conductance | 108, 209 | |
Rodent | Increased ischemic heart injury | 552, 553, 784, 785, 838, 1089, 1100, 1104, 1108 |
Chronic cardiopulmonary dysfunction | 862 | |
Congenital heart disease | 126, 913, 1126 | |
Decreased cardiac output | 359 | |
Decreased ventricular stiffness | 358 | |
Decreased coronary flow reserve | 360 | |
Myocardial thinning | 828 | |
Decreased cardiomyocyte endowment | 47, 49, 553, 767, 985 | |
Matrix metalloproteinases and cardiac remodeling | 986 | |
Increased blood pressure | 794, 851, 859, 945, 1078, 1080, 1083, 1086 | |
Endothelial dysfunction and aging | 23, 99, 184, 310, 365, 690, 839, 1021 | |
Systemic vascular dysfunction | 1061, 1062, 1075, 1079, 1081, 1087 | |
Atherosclerosis | 1037, 1153 | |
Pulmonary vascular dysfunction and hypertension | 445, 621, 797 | |
Metabolic dysfunction | 127, 412, 479, 754, 861 | |
Renal vascular dysfunction | 957 | |
Kidney development defects | 321, 1057, 1071 | |
Reduced bone mass and density | 537 | |
Liver enzyme dysfunction and fatty liver disease | 754, 938 | |
Retinal dysfunction | 100 | |
Changed salt appetite and body fluid regulations | 1117 | |
Impaired respiratory behavior | 795, 796 | |
Altered adrenal medulla maturation | 617 | |
Increased sensitivity to ischemic brain injury | 322, 558, 559 | |
Alzheimer's disease | 1157 | |
Schizophrenia | 385 | |
Sensitized HPA reactivity to stress and anxiety-like behavior | 259, 819, 869, 1033 | |
Impaired circadian synchronization and biological clock to light | 448 | |
Cognitive dysfunctions | 231, 318, 963 | |
Cerebral white matter damage | 1024 |