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. 2018 Aug 2;9:1682. doi: 10.3389/fimmu.2018.01682

Table 2.

Overview of the role exerted by IL-17F in inflammation.

Skin inflammation
  • –

    Human/patient data: IL-17F is increased in psoriatic lesional skin. Elevated levels of IL-17F are found in sera from psoriatic and atopic dermatitis patients (62, 63, 65).

  • –

    Animal models: IL-17F contributes to skin inflammation induced by IMQ application (66, 67).

Joint inflammation
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    Human/patient data: IL-17F is expressed in the synovial tissue from RA patients and contributes to human chronic joint inflammation in vitro and in vivo (62, 70, 71)

  • –

    Animal models: IL-17F is increased in CIA (78), while playing only marginal roles on CIA and arthritis in Il1rn−/− mice (72, 74).

Gut inflammation
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    Human/patient data: IL17F gene expression is increased in active CD (80)

  • –

    Animal models: IL-17F contributes to experimental induced colitis (76, 82)

CNS
  • –

    Human/patient data: IL-17F mRNA is increased in mononuclear cells from MS patients (79)

  • –

    Animal models: Neutralization of IL-17F (alone) does not prevent the development of EAE (77)

Cardiovascular disease
  • –

    Not investigated yet

CNS, central nervous system; IMQ, imiquimod; RA, rheumatoid arthritis; CIA, collagen-induced arthritis; CD, Crohn’s disease; MS, multiple sclerosis; EAE, experimental autoimmune encephalomyelitis.