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(A) The nucleotide sequence of human cytoplasmic tRNAHis including modified nucleosides. Human cytoplasmic tRNAHis in a clover-leaf structure, wherein the 5′-phosphate group is monomethylated (Rosa et al., 1983). (B) Maturation of human cytoplasmic tRNAHis (Gu et al., 2003; Betat et al., 2014) Cytoplasmic tRNAHis has an additional guanosine residue at position-1 (G-1) and an 8-nucleotide-long acceptor helix with G-1:A72 mis-pairing at the top of the acceptor helix (Rosa et al., 1983).
