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. 2018 Aug 3;9:305. doi: 10.3389/fgene.2018.00305

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Copyright © 2018 Tomita and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A model of human Bicoid interacting 3 domain containing RNA methyltransferase (BCDIN3D)-tRNA^His complex structure. Human BCDIN3D structure was modeled using SWISS-MODEL (Biasini et al., 2014), based on the structure of the catalytic domain of methylphosphate capping enzyme (MePCE) (Jeronimo et al., 2007) as a template model. tRNA was manually docked onto the surface of the modeled BCDIN3D and the 5′-terminal of tRNA can enter the catalytic SAM binding site. BCDIN3D measures the length of the acceptor helix of tRNA. (B) A potential association between methylation of tRNA^His and breast cancer. tRNA^His might have unknown functions, beyond its established function in protein synthesis.