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. 2018 Aug 6;9:845. doi: 10.3389/fphar.2018.00845

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Copyright © 2018 Mukai, Kinboshi, Nagao, Shimizu, Ono, Sakagami, Okuda, Fujimoto, Ito, Ikeda and Ohno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of valproate (VPA) on expression of Kir4.1 and GFAP in the hippocampus. (A): Expressional patterns of Kir4.1 channels in astrocytes. Representative images of immunofluorescence double staining for GFAP and Kir4.1 in a medial part of the hippocampal CA1 region. Scale bar: 50 μm. (B) Representative images of immunohistochemical staining for Kir4.1 (left panels) and GFAP (right panels) in the hippocampal CA1 medial regions (medial CA1) and the basolateral amygdaloid nucleus anterior part (BLA) of saline- or valproate (VPA)-treated rats. Scale bar: 200 μm.