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. 2018 Aug 6;9:845. doi: 10.3389/fphar.2018.00845

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Copyright © 2018 Mukai, Kinboshi, Nagao, Shimizu, Ono, Sakagami, Okuda, Fujimoto, Ito, Ikeda and Ohno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-course effects of valproate on topographical Kir4.1/GFAP expression ratios in rats. Animals were treated with 300 mg/kg/day of intraperitoneal valproate for 1 day (A) or 5 days (B). The Kir4.1 expression ratios were calculated as the number of Kir4.1-IR-positive cells relative to the number of GFAP-IR-positive cells in each region. Each point represents the mean ± S.E.M. of six animals. ^*P < 0.05, significantly different from saline-treated rats.