FIG. 5.

In vivo toxicity profiles of PD0325901 and bifunctional inhibitors. (A) Both 0.5 and 1 mg doses of PD0325901 led to adverse events following intravitreal injection compared to control injection with DMSO (vehicle). (B) No adverse events in the retina or retinal vasculature were observed with increasing doses of ST-162 1 week after injection (C) Pronounced toxicity difference between eyes treated with PD0325901 and ST-168 is demonstrated by retinal tear and detachment in PD0325901-treated eye only after 3 days.