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. 2018 Jul 1;34(6):477–485. doi: 10.1089/jop.2017.0126

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Copyright 2018, Mary Ann Liebert, Inc.

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FIG. 6. — Ocular histopathology of rabbit eyes treated with PD0325901 and bifunctional inhibitor ST-168. Representative retinal sections are shown. (A) Intravitreal treatment with 1 mg of PD0325901 caused retinal thinning and tear compared with control injection with DMSO (vehicle). Magnified image (#) shows disorganization of retinal layers (arrow). Transition from normal to abnormal retina is marked by an arrowhead. (B) No histological changes were observed with increasing doses of ST-168 or DMSO vehicle. Magnified inset image (#) shows preservation of retinal layers. *optic nerve.