FIGURE 2.

Anxiety-like behavior in Sort1^−/− mice. (A) Light-dark test, the time spent in the light zone was shorter for Sort1^−/− mice compared to WT mice. (B,C) Elevated-plus Maze test, the ratio of the time spent in the open arm was reduced in Sort1^−/− mice compared to WT mice. The ratio in the number of entries was also reduced in Sort1^−/− mice. (D,E) Glass marbles burying test, the percent of marbles buried by WT mice was significantly increased by Sort1^−/− mice as shown in E. (F) Serum corticosterone level in WT and Sort1^−/− mice remained unchanged. Values are expressed as mean ± SEM. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ns, non-significant.