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Neuronal activity in Sort1−/− mice. (A) Membrane potential mean values obtained on primary cortical neurons prepared from Sort1−/− and WT mice showed an important depolarization in Sort1−/− neurons when compared with WT neurons (ΔmV = 18.21 mV). (B) Dorsal Raphe Nucleus 5-HT neuronal firing activity recorded from WT and Sort1−/− mice. ∗∗∗p < 0.001.
