Figure 4. . Plot of copy number variations generated from 450-k methylation data.

(A) The tumor presented in this case showed no significant copy number variations at 19q13.42 (C19MC). (B) Conversely, a prototypical intracranial medulloepithelioma demonstrated amplification at the 19q13.42 locus; an amplification seen in 95% of tumors labeled as embryonal tumors with multilayered rosettes. This prototypical medulloepithelioma also demonstrated gains at chromosomes 2 and 11q, aberrations frequently observed in embryonal tumors with multilayered rosettes.