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. 2015 Jun 29;4(4):213–224. doi: 10.2217/cns.15.17

Table 2. . Univariate cox proportional hazard model of overall survival using collected demographic and medical factors (n = 991).

Demographic and medical factors p-value Hazard ratio 95% CI of HR Generalized R2 (%)
Age at baseline (years) <0.0001 1.023 1.017–1.029 5.66

Age ≥65 years <0.0001 1.511 1.327–1.722 3.83

KPS score <0.0001 0.973 0.968–0.978 15.89

KPS categories: <0.0001     13.77
– 0–40 vs 80–100 <0.0001 3.930 3.045–5.073  
– 50–70 vs 80–100 <0.0001 1.576 1.307–1.899  
– 0–40 vs 50–70 <0.0001 2.494 1.994–3.121  
– KPS <70 <0.0001 1.968 1.677–2.311 9.71

PPS score <0.0001 0.977 0.972–0.983 12.44

PPS categories: <0.0001     10.60
– 0–40 vs 80–100 <0.0001 3.159 2.343–4.258  
– 50–70 vs 80–100 0.0007 1.493 1.185–1.881  
– 0–40 vs 50–70 <0.0001 2.116 1.639–2.731  
– PPS <70 <0.0001 1.977 1.630–2.398 9.75

Gender 0.0136 1.177 1.034–1.339 0.61

Patients coming from (hospital, home) <0.0001 1.653 1.444–1.892 5.01

Ambulance <0.0001 1.782 1.551–2.047 6.13

Previous radiotherapy 0.4600 0.942 0.804–1.103 0.06

Postoperative 0.0003 0.526 0.371–0.746 1.59

Primary cancer site: 0.0006     2.22
– GI vs breast <0.0001 1.840 1.366–2.479  
– GU vs breast 0.0363 1.381 1.021–1.869  
– Lung vs breast 0.0006 1.365 1.142–1.632  
– Other vs breast 0.0607 1.345 0.987–1.834  
– Unknown vs breast 0.0017 1.681 1.215–2.326  

Dose/fraction (cGy/fractions): 0.0319     0.78
– 2000/5 vs other 0.9975 1.000 0.754–1.328  
– 3000/10 vs other 0.0543 0.680 0.459–1.007  
– 2000/5 vs 3000/10 0.0088 1.471 1.102–1.963  

p < 0.05.

KPS: Karnofsky performance status; PPS: Palliative performance scale.