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. 2018 Aug 3;3(5):e000397. doi: 10.1136/esmoopen-2018-000397

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© European Society for Medical Oncology 2018. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Clinically meaningful worsening (versus improvement or no change)* for AAP (n=46) vs ENZ (n=59) for all PRO scales evaluated. *Defined as the difference from baseline ≥ minimal important difference (0.5 × SD of baseline PRO of all patients). †Evaluable patients. ‡Results could not be obtained from the multivariate repeated measures logistic models for these scenarios due to convergence issues. Instead they are taken from multivariate logistic models fitted for each time period separately. (For all scenarios for which both type of models could be fit, results were very much in line.) Empty cells are the results of zero counts and therefore modelling is not possible. Interpretation of the PRO scales: for FACT-Cog higher scores are favourable; for EORTC QLQ-C30 functional scales and global health status/QoL higher scores are favourable, for EORTC QLQ-C30 symptom scales lower scores are favourable; for BPI-SF and BFI-SF lower scores are favourable.

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