Table 2. In Vitro Cytotoxicity of NAMPT ADCs.
| ADC | linker-payload | linker (L) | target antigen | Aggr. (%) | DAR | GIST-T1 (c-Kit+, nM) | NCI-H526 (c-Kit+, nM) | MDA-MB453 (HER2+, nM) | NCI-N87 (HER2+, nM) |
|---|---|---|---|---|---|---|---|---|---|
| ADC-1 | LP1 | L1 | c-Kit | 29 | 2.8 | 0.014 | >0.720 | not tested | not tested |
| ADC-2 | LP2 | L2 | c-Kit | 23 | 4.0 | <0.003 | 0.047 | >33 | >33 |
| ADC-3 | LP3 | L3 | c-Kit | 6.1 | 3.9 | <0.003 | 0.009 | 2.13 | 4.05 |
| ADC-4 | LP4 | L4 | c-Kit | 5.3 | 2.3 | <0.007 | 0.040 | 6 | 12 |
| ADC-5 | LP4 | L4 | HER2 | 6.2 | 2.9 | 18.7 | 71.5 | 0.006 | 0.017 |
| ADC-6 | LP4 | L4 | IgG | 10 | 4.4 | 0.1274 | 12.5 | 1.42 | 2.76 |
| ADC-7 | LP5 | L5 | c-Kit | 23 | 3.9 | <0.003 | 0.352 | >33 | >33 |