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. 2018 Jul 13;9(8):809–814. doi: 10.1021/acsmedchemlett.8b00200

Table 2. Biological Profile of Compounds 12 and 21.

assay details		Cpd 12 IC₅₀ (μM)^a	Cpd 21 IC₅₀ (μM)^a
enzyme inhibition	ATM	0.00029	0.0007
	mTOR	5.3	21
	DNAPK	1.8	2.8
	PI3Kα	2.2	3.8
	PI3Kβ	8.1	10.3
	PI3Kγ	2.9	3.0
	PI3Kδ	0.80	0.73
cellular inhibition	ATM	0.0019	0.0028
	ATR	>30	>30
	PI3Kα	>30	>30
	PI3Kβ/mTOR	>15	>19

^a

Geometric means of multiple IC₅₀ determinations.