Table 2. Summary of Data for Compounds Matching the PAINS Alerts.
| format | actives | data points | active rate (%) | unique compounds | unique assays | unique gene families | PAINS activity enrichment (odds ratio) |
|---|---|---|---|---|---|---|---|
| AS | 3,490 | 32,471 | 10.8 | 9,813 | 173 | 7 | 2.2 (2.5) |
| ELISA | 1,769 | 7,945 | 22.2 | 5,749 | 134 | 6 | 1.1 (1.1) |
| FB | 8,523 | 102,141 | 8.3 | 11,134 | 721 | 8 | 1.1 (1.1) |
| FP | 5,032 | 39,755 | 12.7 | 11,645 | 201 | 5 | 1.7 (1.5) |
| FRET | 20,794 | 103,973 | 20.0 | 11,101 | 702 | 10 | 1.9 (2.5) |
| SPA | 5,223 | 37,833 | 13.8 | 11,274 | 309 | 10 | 1.0 (1.6) |
| overall | 44,831 | 324,118 | 13.8 | 20,492 | 2,240 | 16 | 1.4 (1.7) |