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Comparison of ABC transporter mediated efflux inhibition by 10 μM of 16a–f (A) and 17a–f (B) on MCF-7/Topo cells (ABCG2; blue), KbV1 cells (ABCB1; red), and MDCKII/MRP1 cell (ABCC1; green); the accumulation of Hoechst 33342 (ABCG2) and calcein (ABCB1 and ABCC1) was measured relative to 10 μM FTC (ABCG2), 10 μM tariquidar (ABCB1), and 30 μM reversan, respectively (100%).
