Table 3.

Percent change in fat mass compared between active and placebo groups using model generated means (LS Means)

Contrast	Treatment	N	LS Mean (SE)	LS Mean Difference (SE)	P Value
Without Baseline Covariates
Capsimax 2 mg vs Placebo	Capsimax 2 mg	27	2.44 (2.14)	−0.82	0.7860
	Placebo	28	3.26 (2.10)
Capsimax 4 mg vs Placebo	Capsimax 4 mg	22	−0.81 (2.37)	−4.07	0.2037
	Placebo	28	3.26 (2.10)
With Baseline Covariates
Capsimax 2 mg vs Placebo	Capsimax 2 mg	26	3.45 (2.79)	−2.43	0.5044
	Placebo	27	5.88 (2.76)
Capsimax 4 mg vs Placebo	Capsimax 4 mg	22	−0.80 (2.37)	−6.68	0.0487
	Placebo	27	5.88 (2.76)

Analysis “Without Baseline Covariates” was a One-way ANOVA model. Analysis “With Baseline Covariates” was a generalized linear model containing treatment, covariates and treatment x covariate interactions. Two subjects were lost to the “With Baseline Covariates” analysis due to missing values at baseline