Scheme 2. Synthetic route to the LOX inhibitors. (i) Mucochloric acid, 50% aq. MeOH, 3 h, 60%; (ii) N-Boc-piperazine, NaI, dioxane, 100 °C, 20 h, 70%; (iii) bisphenol derivative, CuI, Cs₂CO₃, BINOL, dioxane, reflux, 12 h, 58–73%; (iv) 20% TFA in DCM, 1 h, quantitative.