Table 2.
Light adapted ffERG a-wave/b-wave (μV) |
Pupillometry transient constriction |
Pupillometry sustained |
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Patient # | Eye tested | Red 4.5 cd s m−2 stimulus | Blue 4.5 cd s m−2 stimulus | −3 log cd m−2 blue dark adapted (Rod) | 2.6 log cd m−2 red light adapted (Cone) | 2.6 log cd m−2 blue light adapted (Cone) | 2.6 log cd m−2 blue dark adapted (Melanopsin) |
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ESCS1 | OD | 14 / 39 | 183 / 247 | Non-detectable | 46% | 49% | 37% |
ESCS2 | OD | 12 / 15 | 130 / 110 | Non-detectable | 26% | 36% | 47% |
ESCS3 | OD | 20 / 23 | 287 / 213 | Non-detectable | 26% | 34% | 44% |
ESCS4 | OS | 7 / 12 | 59 / 60 | Non-detectable | 29% | 41% | 41% |
ERG controls | 46 - 94 / 146 - 261 | 55 - 92 / 168 - 316 | |||||
Pupillometry controls | 22% - 40% | 37% - 55% | 38% - 55% | 32% - 56% |
Abbreviations: ffERG = full-field electroretinogram; see Methods for stimulus and background wavelengths Pupillometry stimuli are all 1 second duration
The pupillary response is defined as percent relative constriction: [1 − (minimum pupil size) / (baseline pupil size)]×100%
Control data listed are ranges; see Methods for stimulus and background wavelengths