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. 2018 Aug;59(10):4071–4081. doi: 10.1167/iovs.18-24087

Figure 1.

Figure 1

Synthetic steps in forming CDEX NPC. CDEX glucosyl-OH groups are activated with p-nitrophenyl chloroformate in DMSO/pyridine, polymer then isolated by EtOAc precipitation. Pyrrolidyl-PEG-peptide then displaces p-nitrophenol in DMSO to give stable, carbamate-linked peptide. Low stoichiometry Cy7 amine is included during peptide coupling, excess p-nP carbonates are then quenched by excess methoxy-PEG4-amine (not shown).