Figure 2.

Schematic view of CDEX peptide-conjugates (NPC) in vitreous. A hydrophobic cholesteryl domain forms the CDEX NP core. Conjugated PEG-peptides extend outwards. NP are labeled by Cy7 amine, to yield <1 Cy7/NPC. Two types of positively charged peptides were linked at 61 to 64 peptides per NP (lower loading shown for un-crowded view). NPC are immobilized in vitreous by ionic binding between l-Arg guanidinium groups (blue circles) on NPC surface and HA polymer (red circles are HA carboxylate groups).