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. 2018 Aug 10;12:2497–2508. doi: 10.2147/DDDT.S163951

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© 2018 Fang et al. This work is published and licensed by Dove Medical Press Limited

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Baicalin suppressed neural apoptosis induced by TBI.

Notes: (A) Representative images of TUNEL staining surrounding injury site in four groups at 400× magnification. (B) The apoptotic index significantly increased in TBI and TBI + V groups, and Baicalin treatment reversed the change. (C–E) The Western blot bands and semiquantitative analysis of Bcl-2, Bax, and cleaved caspase 3. Data are represented as mean ± SD (n=5, per group). ^##P<0.01 and ^###P<0.001 compared with the sham group; ^*P<0.05 and ^***P<0.001 compared with the TBI + V group. Scale bar: 50 µm.

Abbreviations: B, Baicalin; TBI, traumatic brain injury; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; V, vehicle.