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. 2018 Aug 10;10:2521–2535. doi: 10.2147/CMAR.S168043

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© 2018 Sun et al. This work is published and licensed by Dove Medical Press Limited

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Downregulation of ERRα by XCT790 induces cell apoptosis. The apoptosis rates of EC cell lines RL-952 (A), AN3-CA (B), HEC-1A (C), and HEC-1B (D) induced by XCT790 were analyzed by flow cytometry using an Annexin-V/FITC Kit. Cells treated with 0.1% DMSO (the solvent of XCT790) were called the DMSO group and those treated with 10 µM XCT790 for 24 h were called the XCT group. Downregulation of ERRα by treatment with XCT790 led to a significant increase in the cellular apoptosis as compared to the blank or DMSO group. All experiments were conducted in triplicate. *Significant differences (P<0.05) are indicated.

Abbreviations: FITC, fluorescein-5-isothiocyanate; PI, propidium iodide; EC, endometrial cancer.