Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 10;10:2521–2535. doi: 10.2147/CMAR.S168043

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Sun et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Downregulation of ERRα by siRNA induces cell apoptosis. The apoptosis rates of four endometrial cancer cells RL-952 (A), AN3-CA (B), HEC-1A (C), and HEC-1B (D) infected with siRNA targeted on ERRα (siRNA-ERRα) were analyzed by flow cytometry using an Annexin-V 7AAD Kit. Untreated EC cells were designated as the blank group, the cells infected with nonspecific siRNA as the negative control (NC) group, and the cells infected with siRNA-ERRα for 72 h as the KD group. Compared to the blank or NC group, the downregulation of ERRα by infection with siRNA-ERRα led to a significant increase in cellular apoptosis. All experiments were conducted in triplicate. *Significant differences (P<0.05) are indicated.

Abbreviation: KD, knockdown.