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. 2018 Aug 10;10:2589–2604. doi: 10.2147/CMAR.S165631

Table 1.

Characteristics of literature included in the meta-analysis

Reference Year Region Cancer type Genotype methods Sample size (case/control) Source of control DNA sample Genotype—case Genotype—control HWE
IL-8 −251 A/T AA AT TT AA AT TT
 Shimizu et al48 2008 Asian Oral cancer PCR-FRET 69/91 Population-based Tissue 8 30 31 8 45 38 YES
 Campa et al49,a 2007 European Oral cancer TaqMan 153/725 Population-based Blood 41 72 40 158 370 197 YES
 Campa et al49,b 2007 European Pharynx cancer TaqMan 107/725 Population-based Blood 31 50 26 158 370 197 YES
 Campa et al49,c 2007 European Laryngeal cancer TaqMan 313/725 Population-based Blood 75 141 97 158 370 197 YES
 Campa et al49,d 2007 European Esophageal cancer TaqMan 171/822 Population-based Blood 35 93 43 173 429 220 YES
 Ben Nasr50 2007 African Nasopharyngeal cancer AS-PCR 160/169 Population-based Blood 37 74 49 23 71 75 YES
 Kietthubthew51 2010 Asian Oral cancer Taq-Man 63/99 Population-based Blood 10 21 32 16 49 34 YES
 Zhang 2008 Asian Esophageal cancer PCR-RFLP 320/404 Population-based Blood 50 175 95 74 200 130 YES
 Liu53 2012 Asian Oral cancer PCR-RFLP 270/350 Population-based Blood 42 131 97 66 164 120 YES
 Wei54 2007 Asian Nasopharyngeal cancer PCR-RFLP 280/290 Population-based Blood 54 137 89 42 122 126 YES
 Tai55 2007 Asian Nasopharyngeal cancer PCR-RFLP 105/109 Population-based Blood 11 52 42 17 53 39 YES
 Liu67 2011 Asian Esophageal cancer PCR-HRM 351/384 Hospital-based Blood 19 192 140 42 174 168 YES
 Hu68 2012 Asian Oral cancer PCR-HRM 142/30 Hospital-based Tissue 21 67 54 5 14 11 YES
 Kiliç56 2016 European Thyroid cancer PCR-RFLP 101/109 Population-based Blood 7 41 53 10 50 49 YES
 A. Savage57 2004 Asian Esophageal cancer Single base extension 129/429 Population-based Blood 26 55 48 75 207 147 YES
IL-18 −137 G/C GG GC CC GG GC CC
 Abdolahi58 2015 Asian Thyroid cancer PCR-RFLP 105/148 Population-based Blood 59 33 6 85 56 7 YES
 Babar59 2011 European Esophageal cancer TaqMan 193/1082 Population-based Blood 105 74 14 582 414 86 YES
 Farhat60 2008 African Nasopharyngeal cancer PCR-RFLP 163/164 Population-based Blood 75 73 15 83 68 13 YES
 Asefi61 2008 Asian HNSCC AS-PCR 111/212 Hospital-based Blood 65 37 9 116 79 17 YES
 Tsai62 2013 Asian Oral cancer TaqMan 567/559 Population-based Blood 437 122 8 476 78 5 YES
 Pratesi63 2005 European Nasopharyngeal cancer AS-PCR 89/130 Population-based Blood 43 39 7 72 53 5 YES
 Nong64 2009 Asian Nasopharyngeal cancer PCR-RFLP 250/270 Population-based Blood 140 88 22 189 70 11 YES
 Wei65 2007 Asian Esophageal cancer AS-PCR 235/250 Hospital-based Blood 127 91 17 176 66 8 YES
 Pan69 2013 Asian Nasopharyngeal cancer PCR-RFLP 190/200 Hospital-based Blood 102 74 14 139 52 9 YES
 Chung66 2015 Asian Thyroid cancer Sequencing 94/260 Hospital-based Blood 70 18 6 187 70 3 YES

Note: Superscripted a, b, c and d are parts of one study by Campa et al.49

Abbreviations: HWE, Hardy Weinberg equilibrium; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; AS-PCR, alleles specific polymerase chain reaction; HNSCC, head and neck squamous cell carcinoma; PCR-HRM, polymerase chain reaction-high resolution melt; PCR-FRET, polymerase chain reaction-fluorescence resonance energy transfer.