Table 3.

Systolic blood pressure levels and variability in relation to total burden of cSVD by ordinal logistic regression analysis

	Model 1		Model 2		Model 3
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
24 hours
SBP, mmHg	1.260 (1.093–1.452)	0.001	1.249 (1.079–1.445)	0.003	–	–
SBP SD, mmHg	1.456 (1.170–1.813)	0.001	1.493 (1.194–1.866)	<0.001	1.432 (1.140–1.797)	0.002
Weighted SBP SD, mmHg	1.110 (1.053–1.168)	<0.001	1.765 (1.354–2.303)	<0.001	1.697 (1.297–2.221)	<0.001
SBP CV, %	1.659 (1.239–2.221)	0.001	1.728 (1.279–2.333)	<0.001	2.010 (1.471–2.746)	<0.001
Daytime
SBP, mmHg	1.228 (1.068–1.411)	0.004	1.214 (1.051–1.401)	0.008	–	–
SBP SD, mmHg	1.408 (1.151–1.721)	0.001	1.436 (1.170–1.763)	0.001	1.380 (1.119–1.702)	0.003
SBP CV, %	1.477 (1.123–1.941)	0.005	1.527 (1.153–2.020)	0.003	1.650 (1.241–2.195)	0.001
Nighttime
SBP, mmHg	1.235 (1.089–1.399)	0.001	1.228 (1.082–1.392)	0.001	–	–
SBP SD, mmHg	1.381 (1.119–1.707)	0.003	1.435 (1.155–1.782)	0.001	1.411 (1.133–1.756)	0.002
CV of SBP, %	1.351 (1.048–1.744)	0.020	1.422 (1.093–1.850)	0.009	1.706 (1.289–2.257)	<0.001

Notes: Model 1, adjusted for age and sex; model 2, model 1 + current smoking, current alcohol, diabetes mellitus, hyperlipidemia, body mass index, using antihypertensive drugs; model 3, model 2 + mean SBP during the same period. Results of the ordinal logistic regression analysis were presented as OR per 10 mmHg increase in SBP, 5 mmHg increase in SD, or 5% increase in CV.

Abbreviations: cSVD, cerebral small-vessel disease; CV, coefficient of variation; DBP, diastolic blood pressure; SBP, systolic BP.