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. 2018 Aug 10;11:1511–1519. doi: 10.2147/JPR.S160779

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© 2018 Gao et al. This work is published and licensed by Dove Medical Press Limited

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MaR1 inhibited SNL-induced NF-κB activation and nuclear translocation. (A) Representative immunofluorescent staining of p65 nuclear translocation (arrows) in ipsilateral L4–L5 spinal cord dorsal horn. (B) Western blotting was used to analyze nuclear and cytoplasmic p65 and p65 phosphorylation. Treatment with MaR1 significantly decreased p65 nuclear translocation and phosphorylation. ***P < 0.001 vs sham and ^##P < 0.01 vs SNL. Data are expressed as mean ± SD (n = 10).

Abbreviations: MaR1, maresin 1; SNL, spinal nerve ligation; ACSF, artificial cerebrospinal fluid.