Table 3.
Survival analysis for GC patients with liver metastasis
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Median OS (mo) | 5‐y CSS (95% CI) | P value | Hazard ratio | 95% CI | P value | |
| Sex | ||||||
| Male | 5 | 4.09% (2.89%‐5.60%) | Reference | |||
| Female | 4 | 4.84% (2.97%‐7.36%) | 0.044 | 1.022 | 0.93‐1.13 | 0.662 |
| Age | ||||||
| <66 | 6 | 4.50% (2.92%‐6.57%) | Reference | |||
| >65 | 3 | 4.00% (2.73%‐5.63%) | <0.001 | 1.276 | 1.17‐1.40 | <0.001 |
| Married status | ||||||
| Married | 5 | 4.28% (3.01%‐5.88%) | Reference | |||
| Unmarried | 3 | 3.72% (2.24%‐5.78%) | <0.001 | 1.239 | 1.13‐1.36 | <0.001 |
| Location | ||||||
| Cardia | 6 | 2.98% (1.66%‐4.92%) | Reference | |||
| Fundus | 3 | 7.02% (2.77%‐14.00%) | 0.932 | 0.75‐1.15 | 0.515 | |
| Body | 4 | 5.50% (2.43%‐10.41%) | 1.042 | 0.87‐1.24 | 0.648 | |
| Antrum | 4 | 8.18% (5.08%‐12.19%) | 1.059 | 0.92‐1.22 | 0.428 | |
| Pylorus | 4 | 7.26% (1.74%‐18.33%) | 0.958 | 0.68‐1.35 | 0.808 | |
| Lesser curvature | 6 | 8.19% (3.18%‐18.06%) | 0.870 | 0.71‐1.07 | 0.193 | |
| Greater curvature | 2 | 1.8% (0.16%‐8.25%) | 1.390 | 1.06‐1.83 | 0.019 | |
| Overlapping | 2 | 0 (0) | 1.481 | 1.23‐1.78 | <0.001 | |
| NOS | 3 | 2.65% (0.9%‐6.09%) | <0.001 | 1.255 | 1.10‐1.44 | 0.001 |
| Race/Ethnicity | ||||||
| Caucasian | 5 | 4.13% (2.94%‐5.62%) | — | |||
| African‐American | 4 | 4.32% (1.88%‐8.35%) | — | |||
| Asian | 5 | 4.53% (2.08%‐8.42%) | — | |||
| Others | 4 | 4.20% (0.44%‐15.65%) | 0.9216 | — | ||
| Lauren | ||||||
| Diffuse | 4 | 2.30% (0.58%‐6.32%) | Reference | |||
| Intestinal | 5 | 4.51% (3.37%‐5.89%) | 0.0144 | 0.87 | 0.66‐1.16 | 0.351 |
| Histology subgroup | ||||||
| Adenocarcinoma | 5 | 4.62% (3.49%‐5.97%) | Reference | |||
| Signet Ring cell | 4 | 1.15% (0.11%‐5.30%) | 1.20 | 1.02‐1.41 | 0.029 | |
| Mucinous adenocarcinoma | 3 | 2.40% (0.19%‐10.79%) | 0.0012 | 1.57 | 1.14‐2.18 | 0.006 |
| Grade | ||||||
| Well differentiated | 4 | 3.59% (0.32%‐14.52%) | Reference | |||
| Moderately differentiated | 6 | 6.43% (4.18%‐9.31%) | 0.81 | 0.59‐1.13 | 0.213 | |
| Poorly differentiated | 4 | 3.26% (2.04%‐4.94%) | 1.05 | 0.76‐1.45 | 0.777 | |
| Undifferentiated | 3 | 0 (0) | <0.001 | 0.83 | 0.46‐1.49 | 0.527 |
| Insurance | ||||||
| Insured | 5 | 4.45% (3.36%‐5.74%) | Reference | |||
| Uninsured | 3 | 2.45% (0.25%‐10.10%) | 0.0262 | 1.31 | 1.07‐1.61 | 0.01 |
| Surgery | ||||||
| Yes | 9 | 17.74% (12.18%‐24.16%) | Reference | |||
| No | 4 | 2.95% (1.97%‐4.23%) | <0.001 | 1.82 | 1.52‐2.18 | <0.001 |
OS, Overall survival; CSS, Cause Specific Survival; CI, Confidence Intervals; NOS, Not otherwise specified.