Figure 2.

Modulation of FLI‐1 expression influences the expression of EMT‐related proteins in the breast cancer cells. A, The difference in the expression of EMT‐related proteins in the MDA‐MB231 and MCF‐7 cell lines. B, The changes in the expression of EMT‐related proteins (N‐cadherin, vimentin, E‐cadherin, and Occludin) after the knockdown of FLI‐1 expression in MDA‐MB231 and forced expression of FLI‐1 in the MCF‐7 cells. C, The changes in the expression of EMT‐related genes (N‐cadherin, Vimentin, and E‐cadherin) after the modulation of FLI‐1 expression in the MDA‐MB231 and MCF‐7 cells. Each bar represents mean ± standard deviation (SD). *P < .05. **P < .005. D, The overexpression of FLI‐1 increased the activity VIM (Vimentin) promoter luciferase activity, but distinctly decreased the activity of CDH1 (E‐cadherin) promoter luciferase. Each bar represents mean ± SD. *P < .05