Table 3.

Multivariate Cox regression analyses of CSS to study CRM ≤0.4 mm

Variable	Reference	Characteristic	Cancer‐specific survival
			HR (95%CI)	SE	P value
CRM	≤0.4 mm	0.5‐1.0 mm	0.834 (0.645‐1.078)	0.131	0.166
		1.1‐2.0 mm	0.704 (0.536‐0.924)	0.139	0.012
		2.1‐5.0 mm	0.773 (0.602‐0.992)	0.127	0.043
		5.1‐10.0 mm	0.543 (0.397‐0.741)	0.159	<0.001
		>10.0 mm	0.577 (0.448‐0.742)	0.129	<0.001
AJCC stage	Stage I	Stage II	2.041 (1.388‐3.001)	0.197	<0.001
		Stage III	4.361 (3.060‐6.216)	0.181	<0.001
		Stage IV	15.773 (10.949‐22.722)	0.186	<0.001
Tumor size	Unknown	≤5 cm	0.941 (0.685‐1.292)	0.162	0.707
		>5 cm	1.283 (0.927‐1.775)	0.166	0.133
Age at diagnosis (y)	≤60	>60	1.962 (1.674‐2.298)	0.081	<0.001
Grade	Grade I	Grade II	1.125 (0.738‐1.714)	0.215	0.583
		Grade III	2.077 (1.331‐3.241)	0.227	0.001
		Grade IV	2.899 (1.685‐4.987)	0.277	<0.001
		Unknown	1.027 (0.584‐1.805)	0.288	0.926