Table 1.
Clinicopathological characteristics of 532 patients with gastric cancer undergoing radical gastrectomy
| Variable | All | SMI | COUNT score | |||||
|---|---|---|---|---|---|---|---|---|
| Low (n = 91) | High (n = 441) | P value | Normal (n = 291) | Light (n = 183) | Moderate or severe (n = 58) | P value | ||
| Age (y) | 61.1 (11.5) | 68.4 (11.4) | 59.6 (10.9) | <.001 | 58.8 (11.1) | 62.5 (11.4) | 67.7 (10.3) | <.001 |
| Gender | ||||||||
| Female | 129 (24.2) | 41 (45.1) | 88 (20.0) | <.001 | 72 (24.7) | 36 (19.7) | 21 (36.2) | .036 |
| Male | 403 (75.8) | 50 (54.9) | 353 (80.0) | 219 (75.3) | 147 (80.3) | 37 (63.8) | ||
| BMI (kg/m2) | 21.9 (3.5) | 20 (2.7) | 22.3 (3.5) | <.001 | 22.3 (3.5) | 21.3 (2.9) | 21.7 (4.6) | .012 |
| Tumor site | ||||||||
| Upper | 159 (29.9) | 27 (29.7) | 132 (29.9) | .96 | 79 (27.1) | 65 (35.5) | 15 (25.9) | .119 |
| Not upper | 373 (70.1) | 64 (70.3) | 309 (70.1) | 212 (72.9) | 118 (64.5) | 43 (74.1) | ||
| Tumor size (cm) | 4.5 (2.5) | 3.2 (2.0) | 4.8 (2.5) | <.001 | 4.8 (2.5) | 4.1 (2.3) | 4.4 (2.7) | .006 |
| TNM stage | ||||||||
| I | 165 (31) | 16 (17.6) | 149 (33.8) | .001 | 111 (38.1) | 45 (24.6) | 9 (15.5) | .001 |
| II | 123 (23.1) | 17 (18.7) | 106 (24.0) | 63 (26.6) | 46 (25.1) | 14 (24.1) | ||
| III | 244 (45.9) | 58 (63.7) | 186 (42.2) | 117 (40.2) | 92 (50.3) | 35 (60.3) | ||
| Histological type | ||||||||
| Differentiated | 156 (29.3) | 21 (23.1) | 135 (30.6) | .151 | 88 (30.2) | 50 (27.3) | 18 (31) | .758 |
| Undifferentiated | 376 (70.7) | 70 (76.9) | 306 (69.4) | 203 (69.8) | 133 (72.7) | 40 (69) | ||
| Comorbidities | ||||||||
| No | 390 (73.3) | 55 (60.4) | 335 (76) | .002 | 217 (74.6) | 133 (72.7) | 40 (69) | .659 |
| Yes | 142 (26.7) | 36 (39.6) | 106 (24.0) | 74 (25.4) | 50 (27.3) | 18 (31) | ||
| HB (g/dL) | 12.5 (2.1) | 11.4 (2.6) | 12.8 (2.5) | <.001 | 13.5 (2.1) | 12.0 (2.3) | 9.2 (2.5) | <.001 |
| ALB (g/dL) | 3.8 (0.5) | 3.7 (06) | 3.9 (0.5) | .004 | 4.1 (0.3) | 3.7 (0.4) | 2.9 (0.5) | <.001 |
| Lymphocyte (mm3) | 1770 (620) | 1530 (680) | 1820 (600) | <.001 | 2020 (530) | 1540 (610) | 1280 (510) | <.001 |
| Cholesterol (mg/dL) | 189.5 (85.8) | 182.7 (53.4) | 190.9 (91.7) | .405 | 208.1 (37.6) | 178.0 (130.8) | 131.9 (34.9) | <.001 |
| ASA | ||||||||
| I | 202 (38) | 19 (20.9) | 183 (41.5) | .001 | 130 (44.7) | 66 (36.1) | 6 (10.3) | <.001 |
| II | 312 (59.2) | 69 (75.8) | 246 (55.8) | 154 (52.9) | 111 (60.7) | 50 (86.2) | ||
| III | 15 (2.8) | 3 (3.3) | 12 (2.7) | 7 (2.4) | 6 (3.3) | 2 (3.4) | ||
| Operation method | ||||||||
| Open | 76 (14.3) | 15 (16.5) | 61 (13.8) | .51 | 36 (12.4) | 30 (16.4) | 10 (17.2) | .327 |
| Laparoscopic | 456 (85.7) | 76 (83.5) | 380 (86.2) | 255 (87.6) | 153 (83.6) | 48 (82.9) | ||
| Type of resection | ||||||||
| Subtotal gastrectomy | 297 (55.8) | 49 (53.8) | 248 (56.2) | .676 | 176 (60.5) | 88 (48.1) | 33 (56.9) | .03 |
| Total gastrectomy | 235 (44.2) | 42 (46.2) | 193 (43.8) | 115 (39.5) | 95 (51.9) | 25 (43.1) | ||
| Type of reconstruction | ||||||||
| Billroth I | 250 (47) | 41 (45.1) | 209 (47.6) | .776 | 150 (51.5) | 73 (39.9) | 27 (46.6) | .22 |
| Billroth II | 34 (6.4) | 8 (8.8) | 26 (5.9) | 16 (5.5) | 14 (7.7) | 4 (6.9) | ||
| Roux‐en‐Y | 235 (44.2) | 40 (44) | 195 (44.2) | 116 (39.9) | 93 (50.8) | 26 (44.8) | ||
| Other | 13 (2.4) | 2 (2.1) | 11 (2.5) | 9 (3.1) | 3 (1.6) | 1 (1.7) | ||
| Surgical durations | 189.5 (85.8) | 1856.0 (67.2) | 183.4 (58.1) | .706 | 177.5 (56.9) | 191.9 (64.8) | 190.0 (53.8) | .027 |
| Intraoperative blood loss | 96.2 (192.3) | 79.1 (66.5) | 99.7 (208.9) | .353 | 81.6 (110.1) | 98.6 (132.3) | 161.6 (470.5) | .015 |
| Neurovascular invasion | ||||||||
| No | 400 (75.2) | 64 (70.3) | 336 (76.2) | .239 | 229 (78.7) | 129 (70.5) | 42 (72.4) | .115 |
| Yes | 132 (24.8) | 27 (29.7) | 105 (23.8) | 62 (21.3) | 54 (29.5) | 16 (27.6) | ||
| Adjuvant chemotherapy | ||||||||
| No | 280 (52.6) | 46 (50.5) | 234 (53.1) | .662 | 157 (54.0) | 92 (50.3) | 31 (53.4) | .731 |
| Yes | 252 (47.4) | 45 (49.5) | 207 (46.9) | 134 (46.0) | 91 (49.7) | 27 (46.4) | ||
ALB, albumin; ASA, American Society of Anesthesiologists; BMI, body mass index; COUNT, controlling nutritional status; HB, hemoglobin; SMI, skeletal muscle index.