Table 2.
Summary of the studies describing primary bone marrow non‐Hodgkin lymphoma with hemophagocytic lymphohistiocytosis
| Author | Year | Country | No. of PBMLa | Age | Gender (M:F) | Immunophenotype | Fever | HLH | Outcome | Ref | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B | T | Alive | Dead | |||||||||
| Falini et al | 1990 | Europe | 4 | 53 | 3:1 | 0 | 4 | 4 | 4 | 0 | 4 | 20 |
| Wong et al | 1992 | Hong Kong | 11 | 57 | 7:4 | 4b | 0b | 9 | 6 | 1 | 10 | 8 |
| Ponzoni et al | 1994 | U.S.A | 4 | 68 | 3:1 | 1 | 3 | 4 | 1 | 0 | 4 | 5 |
| Murase et al | 2000 | Japan | 18 | 65 | 9:9 | 18 | 0 | 18 | 18 | 1 | 17 | 22 |
| Gudgin et al | 2005 | UK | 1 | 60 | 1:0 | 0 | 1 | 1 | 1 | 0 | 1 | 21 |
| Kajiura et al | 2007 | Japan | 25 | 66 | 14:11 | 25 | 0 | 21 | 7 | 5 | 20 | 1 |
| Yeh et al | 2010 | Taiwan | 11 | 69 | 8:3 | 11 | 0 | 11 | 7 | 1 | 10 | 2 |
| Li et al | 2014 | Taiwan | 1 | 76 | 0:1 | 1 | 0 | 1 | 1 | 1 | 0 | 23 |
| Total | 75 | 64 | 45(60%):30 | 60 (80%) | 8 (11%) | 69 (92%) | 45 (60%) | 9 (12%) | 66 (88%) | |||
| Wang et al (Current study) | 2018 | Taiwan | 30 | 66 | 18(60%):12 | 23 (77%) | 7 (23%) | 30 (100%) | 20 (67%) | 7 (23%) | 23 (77%) | |
F, female; HLH, hemophagocytic lymphohistiocytosis; M, male; No., number of patients; PBML, primary bone marrow lymphoma.
a
Various enrollment criteria were adopted in these studies; however, only PBML cases are included in his table.
b
In Wong's study (Ref. 8), four patients had B‐cell immunophenotype, one had non‐B & non‐T immunophenotype, and the rest six patients were unavailable.