Figure 8.

The Schematic Diagram Elucidates the Mechanism Whereby IAP Antagonists Induce G2/M Phase Arrest in MB Cells. IAP antagonists LBW242 and LCL161 induce MB cell cycle arrest in the G2/M phase through decreased expression of cIAP1, cIAP2, and XIAP. G2/M phase arrest is attributed to attenuation of cyclin A‐CDK1/2 and cyclin B‐CDK1. Downregulated cIAP1 expression fails to induce neddylation (NEDD8)‐mediated proteasomal degradation of p21, resulting in elevation of p21 protein levels which consequently disturbs the cell cycle in MB cells