Table 5.
Brain activation amplitude differences between the ADHD-NONE taxometrically- determined subgroup and non-ADHD. The table lists Montreal Neurological Institute stereotactic space coordinates of peak study group difference for each cluster that was found to be significant in two-sample t test (p<.001 corrected for searching the whole brain). Results are reported for motor inhibition and error processing on the Go/NoGo task and reward prospect and reward anticipation for the Monetary Incentive Delay task. For each brain region, the Cohen’s d effect size is depicted using sparkline graph to facilitate comparison of ADHD subgroup differences with non-ADHD. The final columns report omnibus F significance p levels from a secondary ANOVA comparing the ADHD subgroups. Subgroup ANOVA-identified regions that survive False Discovery Rate corrections for multiple comparisons are denoted with †.
| Max Peak x, y, z |
t | Effect Size Pattern* | ADHD Subgroup ANOVA | ADHD Subgroup Activation Level Pairwise | |
|---|---|---|---|---|---|
| Motor Inhibition HC > ADHD-NONE | |||||
| Left caudate | −6, 17, 2 | 2.91 |
|
.010 † | EF, NONE < REW/EF |
| Motor Inhibition ADHD-NONE > HC | |||||
| Cerebellum (X) | −3, −43, -37 | 4.26 |
|
.101 | - |
For sparkline graphs, the initial grey datapoint represents the Cohen’s d effect size from a supplemental two-sample t test that compared non-ADHD to all of the ADHD participants. Afterwards, subgroups ADHD1, ADHD2, and ADHD3 are depicted. All sparkline values on this table are scaled relative to the maximum Cohen’s d=1.01 found across all four fMRI task conditions for the ADHD3 subgroup.