Table 1.

Clinical and pathological features of controls and ET cases

Variables	Controls	ET cases	p value
n	30	60
Age at death (years)	85.2 ± 5.7	86.0 ± 6.6	0.57b
Age of tremor onset (years)	NA	44.0 ± 21.6	NA
		Median = 47.5
Duration of symptoms (years)	NA	42.0 ± 21.5	NA
		Median = 39.0
Gender			0.23c
Male	15 (50.0%)	22 (36.7%)
Female	15 (50.0%)	38 (63.3%)
Total tremor scores	NA	12.45 ± 3.19	NA
Purkinje cell countsa	10.52 ± 1.49	8.82 ± 1.48	<0.001b
Torpedo counts	3.90 ± 3.28	15.38 ± 15.02	<0.001d
	Median = 3.00	Median = 12.00
Heterotopic Purkinje cell counts	6.23 ± 11.45	7.65 ± 9.14	0.020d
	Median = 2.00	Median = 4.50
Hairy basket ratings	1.57 ± 0.61	2.00 ± 0.78	0.004d
	Median = 1.50	Median = 2.00
Purkinje cell axonal recurrent collateral counts	1.01 ± 1.16	1.88 ± 1.53	0.006d
	Median = 0.60	Median = 1.42
Purkinje cell thickened axonal profile counts	0.96 ± 1.60	1.76 ± 2.32	0.017d
	Median = 0.55	Median = 1.09
Purkinje cell axonal branching counts	0.09 ± 0.10	0.37 ± 0.40	<0.001d
	Median = 0.07	Median = 0.27

Values represent mean ± standard deviation or number (percentage), and for variables with non-normal distribution, the median is reported as well

NA not applicable

^aMean number of Purkinje cell counts (PCs) per ×100 microscopic field, among 15 sampled fields

^bIndependent samples t test

^cChi-square test

^dIndependent samples Mann-Whitney U test

The italicized entries are statistically significant