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. Author manuscript; available in PMC: 2018 Aug 13.
Published in final edited form as: Cell Rep. 2018 Jun 12;23(11):3137–3145. doi: 10.1016/j.celrep.2018.05.036

Figure 4. CaMKII Activation Drives the oAβ-Mediated Dendritic Spine Loss.

Figure 4.

(A) Sample images of dendritic regions from hippocampal neurons overexpressing the synaptic marker Homer1c::DsRed. Note that a prolonged incubation with oAb (0.5 μM for5 hr) promoted spine loss (yellow arrowheads) that was blocked by both the GluN2B-antagonist ifenprodil and the CaMKII inhibitors KN93 and tatCN21. Scale bar, 5 μm.

(B) Bar graph of the mean ± SEM survival fraction after oAβ incubation. Ctrl = 102.5% (n = 4 neurons), oAβ.= 80% (n = 15neurons), oAβ + ifenprodil = 102.5% (n = 4 neurons), oAβ + KN93 = 100.5% (n = 7 neurons), oAβ + KN92 = 75.6% (n = 8 neurons), and oAβ + tatCN21 = 99.7% (n = 9 neurons).