Table 3.
Variables | Sporadic ET | Familial ET
|
p value
|
||
---|---|---|---|---|---|
Liberal criterion | Conservative criterion | Sporadic ET vs. familial ET liberal criterion | Sporadic ET vs. familial ET conservative criterion | ||
n | 29 | 31 | 26 | ||
Age at death (years) | 87. ± 4.8 | 85.6 ± 5.9 | 85.7 ± 6.1 | 0.030a | 0.208a |
Age of tremor onset (years) | 48.8 ± 20.3 | 36.8 ± 21.5 | 33.6 ± 20.6 | 0.024b | 0.007b |
Median = 55.0 | Median = 40.0 | Median = 33.50 | |||
Duration of tremor (years) | 38.7 ± 22.1 | 49.0 ± 20.9 | 52.3 ± 20.2 | 0.070a | 0.022a |
Gender | 0.639c | 0.825c | |||
Male | 12 (41.4%) | 11 (35.5%) | 10 (38.5%) | ||
Female | 17 (58.6%) | 20 (64.5%) | 16 (61.5%) | ||
PC counts | 8.6 ± 1.4 | 9.3 ± 1.3 | 9.4 ± 1.3 | 0.107a | 0.093a |
Torpedo counts | 23.2 ± 24.9 | 31.4 ± 30.6 | 29.4 ± 32.8 | 0.348b | 0.684b |
Median = 15.0 | Median = 21.0 | Median = 21 | |||
CF synaptic density (puncta/100 μm) | 18.0 ± 2.1 | 17.9 ± 2.5 | 17.9 ± 2.6 | 0.748b | 0.689b |
Median = 18.0 | Median = 18.0 | Median = 17.5 | |||
Percentage of CFs extending into the PF territory | 28.1 ± 6.8 | 29.7 ± 6.8 | 29.4 ± 7.0 | 0.396a | 0.494a |
Values represent mean ± standard deviation or number (percentage), and for variables with a non-normal distribution, the median is reported as well. Mean number of PC counts per 100 × microscopic field, among 15 sampled fields. Bolded values are significant (with Bonferroni correction).
Abbreviations: PC: Purkinje cells, CF: climbing fiber, PF: parallel fiber.
Independent samples t-test.
Independent samples Mann-Whitney U test.
Chi-square test.