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. 2018 Aug 8;8(8):e021623. doi: 10.1136/bmjopen-2018-021623

Table 3A.

Risk factors for study outcomes, multivariable estimates (GA at enrolment ≤20 weeks)

Characteristics Study outcomes
Caesarean sections
n=11 628, 24%
RR (95% CI)†
Pregnancy-related
maternal complications
n=6762, 14%
RR (95% CI)†
Stillbirths
n=1104, 2.3%
RR (95% CI)†
Neonatal deaths
(within 28 days of birth)
n=963, 2.0%
RR (95% CI)†
Low birth weight
(<2500 g)
n=8378, 18%
RR (95% CI)†
Mother’s age (years)
 <20 0.83†* (0.73 to 0.95) 0.83* (0.72 to to 0.97) 0.73 (0.47 to 1.12) 1.23 (0.87 to 1.75) 1 (0.88 to –1.15)
 20–29 Ref Ref Ref Ref Ref
 >29 1.56** (1.44 to 1.68) 1.37** (1.22 to 1.53) 1.45* (1.13–1.86) 1.37* (1.03 to 1.80) 1.27** (1.15 to 1.40)
Mother’s education (grades)
 Primary or less (≤4) 0.50** (0.46 to 0.54) 0.76** (0.70 to 0.83) 1.68** (1.39 to 2.04) 1.53** (1.24 to 1.87) 1.17** (1.08 to 1.25)
 Secondary (5–10) 0.70** (0.67 to 0.73) 0.90** (0.85 to 0.94) 1.40** (1.21 to 1.61) 1.30** (1.12 to 1.52) 1.15** (1.09 to 1.21)
 University (>10) Ref Ref Ref Ref Ref
Parity
 Nulliparous 1.33** (1.28 to 1.39) 2.00** (1.86 to 2.15) 1.32** (1.17 to 1.50) 1.57** (1.38 to 1.80) 1.38** (1.31 to 1.44)
 1–2 Ref Ref Ref Ref Ref
 >2 0.49** (0.40 to 0.60) 0.80* (0.63 to 1.00) 1.50* (1.06 to 2.13) 1.62* (1.10 to 2.37) 0.99 (0.85 to 1.17)
Anaemia (g/dL)
 Severe/moderate (<10) 0.89** (0.84 to 0.95) 0.90* (0.83 to 0.98) 1.16 (0.92 to 1.46) 1.37* (1.06 to 1.77) 1.24** (1.14 to 1.35)
 Mild (10–11) 0.91* (0.86 to 0.97) 0.92* (0.85 to 0.99) 1.12 (0.88 to 1.41) 1.16 (0.90 to 1.50) 1.09 (1.00 to 1.18)
 Normal (≥11) Ref Ref Ref Ref Ref
Body mass index (kg/m2)
 Underweight (<18.5) 0.81** (0.77 to to 0.84) 0.83** (0.79 to 0.88) 1.08 (0.96 to 1.22) 1.09 (0.96 to 1.24) 1.18** (1.13 to 1.23)
 Normal (18.5–24.9) Ref Ref Ref Ref Ref
 Overweight or obese (≥25) 1.64** (1.51 to 1.78) 1.44** (1.28 to 1.61) 1.19 (0.84 to 1.67) 1.25 (0.87 to 1.79) 0.91 (0.79 to 1.04)

*P<0.05, **p<0.001.

†Obtained by multivariable GEE regression models for each outcome, separately.

GA, gestational age; GEE, generalised estimating equations.