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. 2018 Aug 2;9:877. doi: 10.3389/fphys.2018.00877

FIGURE 4.

FIGURE 4

T-CD4 cell fate as a function of exogenous cytokine concentrations define diverse phenotype-associated environments. From the Th0 initial state, a CD4+ T cell evolves to different phenotypes, depending on critical concentrations of environmental cytokines as shown in Table 1: Th1 (IFNG and IL12), Th2 (IL4, Il2), Th17 (Il21, TGFB), Treg (IL2, TGFB), Tfh (IL21), Th9 (IL4, TGFB), Tr1 (IL10, IL27), and Th3 (TGFB). The plot shows the difference between the values of the initial Th0 state and the final steady state at different concentrations of exogenous cytokines. The transition may be abrupt or gradual and, interestingly, may involve an intermediate state, as in the cases Th0 - > Tfh - > Th17 (C), and Th0 - > Th3 - > Th9 (F).