Table 1.

CD4+ T cell types, their associated transcription factors, characteristic cytokines, and exogenous cytokines that induce the cell type.

Cell type	Transcription factor	Characteristic cytokines	Induced by
Th1	T-bet	IFNγ	IFNγ, IL-12
Th2	GATA3	IL-4	IL-4, IL-2
Th17	RORγt	IL-17, IL-21	TGFβ, IL-6, IL-21
Tfh	Bcl6	IL-21	IL-21
Th9	-	IL-9	TGFβ, IL-4
iTreg	Foxp3	TGFβ	TGFβ, IL-2
Tr1	-	IL-10	IL-10, IL-27
Th3	-	TGFβ	TGFβ