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Exogenous cytokines in different environments included in the CD4+ T cell regulatory network.
| Micro-environment | Active input nodes |
|---|---|
| pro-Th0 | None |
| pro-Th1 | IFNGe, IL12e |
| pro-Th2 | IL2e, IL4e |
| pro-Th17 | IL21e, TGFBe |
| proTh9 | IL4e, TGFBe |
| proTfh, | IL21e |
| pro-iTreg | IL2e, TGFBe |
| pro-Tr1 | IL10e, IL27e |
| pro-Th3 | TGFBe |
Active nodes refer to the same exogenous cytokines, whose concentrations were modified during the simulation, adopting values between 0 and 1.
