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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Thromb Res. 2018 Jun 1;168:53–59. doi: 10.1016/j.thromres.2018.05.032

Table 3.

Replication of Associations between the JMJD1C SNPs and FVII in the EA participants of CHS, FHS, and RS studies

SNP All CHS (FVIIc, N=3,266) FHS (FVII antigen, N=2,801) RS (FVIIc, N=1,473) Meta-analysis
A1/A2 AF1 Beta SE P AF1 Beta SE P AF1 Beta SE P Meta_p1 Meta_p2
rs1935* C/G 0.50 1.18 0.61 0.05 0.53 0.15 0.43 0.73 0.51 1.55 0.97 0.11 0.03 0.01
rs10740118† C/G 0.46 −1.43 0.68 0.04 0.41 0.28 0.44 0.53 0.41 −0.89 0.99 0.37 0.17 0.03
*

imputation quality >0.97 in all three studies

†

imputation quality =0.79 in CHS and >0.99 in FHS and RSM

A1: coded allele; A2: non-coded allele; AF1: allele frequency of A1; Beta: refers to the phenotype change per 1 copy of A1 allele; SE=standard error

Meta_p1= p-value from meta-analysis of CHS, FHS and RS data using p-value and direction of association weighted by sample size of each study; Meta_p2= p-value from meta-analysis of CHS and RS data using effect size (beta) and standard error of each study.